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Prednisone is classified under the drugs called immunosuppressant. It practically affects the function of the immune system. This is used to suppress diseases related to inflammation and used for patients with cancer in higher doses, but it has vital adverse effects. It is usually in tablet form (taken orally) but can also be delivered on some other routes via IM (intramuscular injection) and IV (intravenous injection). Prednisone is considered to be a drug which is administered on its inactive state, which is then metabolized in the liver and changed into prednisolone, which is a steroid.
Prednisone was on the market since 1955 and was synthesized in the laboratories of the Schering Corporation, presently known Schering-Plough Corporation, by Arthur Nobile and his colleagues. They were able to find out that cortisone can be oxidized to change into prednisone with the use of a bacterium called Cornybacterium simplex. These treatment medicines are now offered from a number of manufacturers as generic drugs.
This is used on patients who are suffering from inflammatory disease such as severe cases of asthma, ulcerative colitis, rigorous allergies, Bell’s palsy, Crohn’s disease, pemphigus, sarcoidosis, and etc. This drug is also used to prevent the occurrence of tumors. Prednisone is very vital in the management of acute lymphoblastic leukemia, Hodgkin’s lymphoma, multiple myeloma and other tumors in mixture with other chemotherapeutic drugs. This is also used to delay the incidence of Herxheimer reaction and to interrupt the start of symptoms of Duchene muscular dystrophy. However, the mechanism of delay is still unproven and unknown. And because one of its effects is to suppress the function of the adrenals, it is occasionally used in the healing of congenital adrenal hyperplasia.
Short-term side effects which can be experienced include hyperglycemia (increase in blood glucose level), especially on patients which are suffering from diabetes mellitus and a mineralocorticoid effects such as edema (fluid retention). Other short-term side effects include insomnia, mania and euphoria (mental state to experience an exaggerated feeling of well-being).